Carrier Gas Migration Services: Helium to Hydrogen or Nitrogen Conversion for GC Laboratories

OUR CLIENTS

Quest Diognostics

Quest Diognostics

Pharmasol

Pharmasol

CoNCERT

CoNCERT

Aspenti health

Aspenti health

Tarveda

Tarveda

Dr. Reddy's

Dr. Reddy's

RTI International

RTI International

Genzyme

Genzyme

Blend Therapeutics

Blend Therapeutics

Abbott

Abbott

Harvard University

Harvard University

Massachusetts Institute of Technology

Massachusetts Institute of Technology

Test America

Test America

Sunkist

Sunkist

Boston university

Boston university

Phenomenex

Phenomenex

USGS

USGS

Pionee

Pioneer

Schwabe

Schwabe

Pfizer

Pfizer

Translate bio

Translate bio

Amgen

Amgen

USPS

USPS

Carrier Gas Migration Services


Helium shortages and rising costs are pressuring laboratories that rely on helium for gas chromatography (GC). Switching to hydrogen or nitrogen may work for certain analytical methods, but the change requires careful evaluation.


Overbrook Support Services helps laboratories evaluate and plan carrier-gas conversions, considering analytical performance, instrument compatibility, safety, and operating requirements.

Discuss Your Laboratory’s Carrier Gas Options

Can Your Laboratory Convert from Helium to Hydrogen or Nitrogen?

Many gas chromatography applications may be candidates for alternative carrier gases. Hydrogen can offer efficient separations and potentially faster analysis times, while nitrogen may provide a cost-effective option for methods that can accommodate slower carrier gas velocities.


The right choice depends on your laboratory’s equipment, analytical methods, and testing requirements. Not every GC or GC-MS application is suitable for conversion.

What Does Overbrook’s Carrier Gas Migration Service Include?

Overbrook helps laboratories evaluate the technical requirements and plan an appropriate transition.


1. Carrier Gas Process Analysis

Review current helium use, analytical methods, and GC instrumentation to identify opportunities for conversion.


2. Hydrogen and Nitrogen Carrier Gas Evaluation

Assess alternative gases based on instrument compatibility, analytical performance, safety considerations, and operational needs.


3. GC Method Development and Conversion

Identify method adjustments and conversion requirements needed to maintain appropriate analytical performance.


4. GC Equipment and Hardware Retrofitting

Evaluate potential equipment modifications required to support the selected carrier gas.

Which Gas Chromatography Applications May Be Suitable for Carrier Gas Conversion?

Depending on the instrument and method requirements, potential applications include:

  • Gasoline and petroleum analysis
  • Total petroleum hydrocarbons (TPH)
  • Environmental testing, including pesticides and PCBs
  • Semi-volatile organic compounds
  • Pharmaceutical residual solvent analysis
  • Essential oils and flavor analysis

Each application requires an individual assessment to determine whether conversion is appropriate.

The first step is to understand which methods and instruments can support an alternative carrier gas.

How Can Your Laboratory Reduce Helium Dependence Without Compromising Analytical Requirements?

Overbrook can assess your existing GC operations, identify conversion opportunities, and develop a migration plan tailored to your laboratory.

Download Our Carrier Gas Migration Technical Overview


Learn more about helium alternatives, potential GC applications, and the technical considerations involved in transitioning to hydrogen or nitrogen.

Download the Carrier Gas Migration Datasheet