About LCMS
How Does LCMS Work?
With the resolving power of liquid chromatography combined with the detection specificity of mass spectrometry, LCMS is a powerful analytical technique. This technique separates a sample component that is then introduced into a mass spectrometer. This process allows for the analysis of samples that have historically been challenging to analyze.
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What is Mass Spectrometer?
A mass spectrometer is a tool that allows molecules to be deflected through magnetic fields. The first step in the mass spectrometry sequence is ionization. During this process the atoms are ionized by removing at least one electron to generate a positive ion. Next, the ions are accelerated to generate the same kinetic energy. The third step is deflection. These ions are then deflected by a magnetic field. The lighter the ion the more deflection they will experience. Finally, this beam of ions can be detected electrically.
Differences between LCMS and LMCS-MS and HPLC
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What is MS Detection?
Mass spectrometry detection is a method that uses the mass-to-charge ratio of a compound. After the chromatographic separation of the compound, the molecules are ionized and sent through a set of magnets to further separate these molecules based on their mass-to-charge ratio. As these charged particles strike a detector and create current, the molecules can be identified. Because different charges and masses can be detected, MS detection allows for more specificity.
What Applications Does LCMS Support?
From environmental analysis to pharmaceutical development, LCMS supports a wide range of applications. Molecular weight detection of proteins can be done quickly and accurately with LCMS. Combinatorial chemistry has changed the drug discovery process. With LCMS compounds no longer having to be created with manual manipulations. Entire classes of compounds can now be generated from sets of reagents. For pharmaceutical applications, the mass spectrum made available from LCMS can provide information through separating compounds that are chromatographically unresolved.
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What is LCMS?
Liquid Chromatography, or Liquid Chromatography for Mass Spectrometry is the most common bioanalytical method used in laboratories today. This methodology, along with tandem mass spectrometry, LCMSMS offers a robust, versatile, and sensitive appropriate for small molecules.
LCMS Questions
Opting for contract maintenance for your laboratory's equipment is a big decision. As with any big decision, you should have a few questions. Here is what you need to ask before selecting a contract maintenance provider.
To ensure a product is safe and meets its intended use, method validation, and instrument qualifications are necessary Qualifications (IQ/OQ/PQ) provide a systematic approach to confirming that each instrument is proven to be accurate and precise. This process should be both scientifically strict, but also straightforward and repeatable.
Periodic maintenance is important for the functionality of your lab's equipment. So is qualification. But how are they different?
